CAS No.: 202592-23-2
(S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetic acid Catalog No. CSN18086
Synonyms: (+)-JQ1-COOH;(+)-JQ-1 Carboxylic Acid;(+)-JQ1 (free acid)
(+)-JQ1 carboxylic acid is a warhead ligand with a carboxylic acid functional group for conjugation reactions of PROTAC targeting on BET.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
动物研究 剂量 Mice: 50 mg/kg[4] (i.p.)
给药途径 i.p.
- 参考文献
- [1] Gadd MS, Testa A, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.
- [2] Zengerle M, Chan KH, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015 Aug 21;10(8):1770-7.
- [3] Winter GE, Buckley DL, et al. DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation. Science. 2015 Jun 19;348(6241):1376-81.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 202592-23-2 | 储存条件 |
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| 分子式 | C19H17ClN4O2S | 运输 | 蓝冰 | |||||
| 分子量 | 400.88 | 别名 | (+)-JQ1-COOH;(+)-JQ-1 Carboxylic Acid;(+)-JQ1 (free acid);JQ1-Carboxylic Acid;JQ-1 Acid;202592-23-2 (free) | |||||
| 溶解度 |
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动物实验配方 |
